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ClinVar has an entry for this variant (Variation ID: 574387). Variants that disrupt the consensus splice web-site are a relatively typical explanation for aberrant splicing (PMID: 17576681, 9536098). Algorithms formulated to predict the outcome of sequence improvements on RNA splicing propose this variant may well develop or strengthen a splice web page. In summary, the offered evidence is at this time insufficient to determine the job of this variant in sickness. For that reason, it's been categorized to be a Variant of Uncertain Importance. (less)

ClinVar includes an entry for this variant (Variation ID: 574387). Variants that disrupt the consensus splice internet site are a relatively popular cause of aberrant splicing (PMID: 17576681, 9536098). Algorithms formulated to predict the result of sequence improvements on RNA splicing advise that this variant may possibly develop or fortify a splice internet site. In summary, the out there proof is at present insufficient to find out the role of this variant in sickness. Hence, it has been labeled like a Variant of Unsure Significance. Okay

These citations are determined by LitVar utilizing the rs selection, so They could incorporate citations for multiple variant at this area. Please evaluate the LitVar final results diligently for the variant of curiosity. History final up to date Could 19, 2024 

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Stars represent the evaluate standing, or the level of review supporting the submitted (SCV) history. This price is calculated by NCBI based upon facts within the submitter.

Examine to learn about the 777 On line casino login and registration approach. This post further more provides insights about the issues that will maybe be confronted by players and how to deal with them.

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Study our regulations for calculating the review status. This column also includes a link for the submitter’s assertion standards if delivered, and the collection approach.

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